Analysis into conolidine has resulted in discovery of the opioid receptor in the human body called ACKR3/CXCR7. ACKR3 is apparently by far the most popular focus on for conolidine, which also disregards the other 4 classical opioid receptors(3). Supplied the system of action of conolidine as opposed to opioids https://www.proleviate.com/post/conolidine-an-alternative-natural-pain-relief-to-replace-traditional-painkillers